In the great meatloaf debate, choosing between ground chuck and ground beef can be tricky. Ground chuck is often favored for its rich flavor and ideal fat content, which yields a moist and flavorful meatloaf. On the other hand, ground beef, particularly lean ground beef, can result in a drier, less flavorful dish. However, it's a good choice for those watching their fat intake. Ultimately, the best choice depends on your personal preference for taste and health considerations.